Description

8-Chloro-3-Cyclobutylimidazo[1,5-A]Pyrazine is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly in kinase inhibitor programs. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and contract research organizations (CROs) engaged in the synthesis of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its imidazopyrazine scaffold.
• Chemical Biology Probes: Serves as a core structure for developing selective chemical probes to study specific biological pathways and target validation.
• Preclinical Drug Development: Employed in the synthesis of candidate compounds for pharmacokinetic and pharmacodynamic evaluation.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and cGMP production of active pharmaceutical ingredients (APIs) under development.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	8-Chloro-3-Cyclobutylimidazo[1,5-A]Pyrazine
CAS No.	867166-09-4
Molecular Formula	C10H9ClN4
Molecular Weight	220.66 g/mol
Synonyms	8-Chloro-3-cyclobutylimidazo[1,5-a]pyrazine; Imidazo[1,5-a]pyrazine, 8-chloro-3-cyclobutyl-; 3-Cyclobutyl-8-chloroimidazo[1,5-a]pyrazine; 867166-09-4; 8-Chloro-3-cyclobutyl-imidazo[1,5-a]pyrazine; 8-Chloro-3-cyclobutylimidazo[1,5-a]pyrazine (CAS 867166-09-4)
EINECS	Contact for details

Quality Control

Our 8-Chloro-3-Cyclobutylimidazo[1,5-A]Pyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to supply chain reliability and documentation transparency supports your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.