Description

8-Chloro-3-Cyclobutyl-1-Iodoimidazo[1,5-A]Pyrazine is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated imidazopyrazine core. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics targeting various disease pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probe Development: Serves as a scaffold for creating molecular probes to study biological pathways and protein functions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up synthesis under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for heterocyclic chemistry research and methodology development.
• Library Synthesis: A valuable reactant for generating diverse compound libraries for high-throughput screening (HTS).

Basic Information

Product Name	8-Chloro-3-Cyclobutyl-1-Iodoimidazo[1,5-A]Pyrazine
CAS No.	867165-15-9
Molecular Formula	C10H9ClIN3
Molecular Weight	333.55 g/mol
Synonyms	8-Chloro-3-cyclobutyl-1-iodoimidazo[1,5-a]pyrazine; Imidazo[1,5-a]pyrazine, 8-chloro-3-cyclobutyl-1-iodo-; 1-Iodo-8-chloro-3-cyclobutylimidazo[1,5-a]pyrazine; 867165-15-9; 8-Chloro-3-cyclobutyl-1-iodo-imidazo[1,5-a]pyrazine; CAS 867165-15-9
EINECS	Contact for details

Quality Control

Our 8-Chloro-3-Cyclobutyl-1-Iodoimidazo[1,5-A]Pyrazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥97.0%
Assay	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.