Description

4-(3,3,3-Trifluoro-2-Hydroxy-Propyl)-Piperazine-1-Carboxylic Acid Ethyl Ester is a high-value, fluorinated piperazine derivative that serves as a critical synthetic intermediate in advanced pharmaceutical research and development. Its unique structure, featuring a trifluoromethyl and hydroxyl group, makes it a versatile building block for constructing complex molecules with enhanced metabolic stability and bioavailability. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the trifluoromethyl group can improve activity and environmental profile.
• Fluorinated Compound Synthesis: Serves as a precursor for introducing the 3,3,3-trifluoro-2-hydroxypropyl moiety into more complex molecular architectures.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of fluorination and hydroxylation on biological activity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions.

Basic Information

Product Name	4-(3,3,3-Trifluoro-2-Hydroxy-Propyl)-Piperazine-1-Carboxylic Acid Ethyl Ester
CAS No.	866135-53-7
Molecular Formula	C11H19F3N2O3
Molecular Weight	284.28 g/mol
Synonyms	Ethyl 4-(3,3,3-trifluoro-2-hydroxypropyl)piperazine-1-carboxylate; 1-Carbethoxy-4-(3,3,3-trifluoro-2-hydroxypropyl)piperazine; 4-(3,3,3-Trifluoro-2-hydroxypropyl)piperazine-1-carboxylic acid ethyl ester; 1-Piperazinecarboxylic acid, 4-(3,3,3-trifluoro-2-hydroxypropyl)-, ethyl ester; NSC 797080; CAS 866135-53-7
EINECS	Contact for details

Quality Control

Our production of 4-(3,3,3-Trifluoro-2-Hydroxy-Propyl)-Piperazine-1-Carboxylic Acid Ethyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development projects with material produced under quality management systems designed to meet the needs of pre-clinical and early-phase clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.