Description

Magnesium, Chloro-2-Thiazolyl- (9Ci) is a specialized organomagnesium reagent, a key building block in modern synthetic chemistry. This compound matters for its role as a highly reactive nucleophile, enabling the efficient formation of carbon-carbon and carbon-heteroatom bonds in complex molecule construction. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel thiazole-containing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for constructing thiazole rings and introducing functional groups in the development of new active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides that incorporate the biologically active thiazole moiety.
• Cross-Coupling Reactions: Serves as an organometallic coupling partner in Negishi, Kumada, and related palladium-catalyzed cross-coupling reactions to form biaryl and complex alkyl-aryl structures.
• Nucleophilic Addition Reactions: Employed for the addition to carbonyl compounds (aldehydes, ketones) and electrophilic carbon centers to build molecular complexity.
• Material Science Precursor: Acts as a precursor in the development of organic electronic materials and metal-organic frameworks (MOFs) with tailored properties.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the efficient, large-scale production of target molecules.

Basic Information

Item	Details
Product Name	Magnesium, Chloro-2-Thiazolyl- (9Ci)
CAS No.	866029-48-3
Molecular Formula	C3H2ClMgNS
Molecular Weight	134.87 g/mol
Synonyms	2-Chlorothiazol-5-ylmagnesium; (5-Chloro-1,3-thiazol-2-yl)magnesium; 2-Chloro-1,3-thiazol-5-ylmagnesium; Chloro-2-thiazolylmagnesium; 5-Chlorothiazol-2-ylmagnesium; Grignard Reagent of 2-Chlorothiazole; 2-Chlorothiazole magnesium derivative
EINECS	Contact for details

Quality Control

Our Magnesium, Chloro-2-Thiazolyl- (9Ci) is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, concentration (typically supplied as a solution in THF or diethyl ether), and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the exacting standards of pharmaceutical R&D and commercial production.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and easily oxidized nature, this reagent must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions to maintain stability and reactivity. The storage area must be dry, well-ventilated, and free from ignition sources.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (on an anion-free basis)
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.