Description

4-Thioanisolemagnesium Bromide is a highly reactive organometallic Grignard reagent, essential for advanced organic synthesis. Its core value lies in its ability to act as a powerful nucleophile for the formation of carbon-sulfur and carbon-carbon bonds, enabling the construction of complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the synthesis of novel thioether-containing compounds and fine chemicals.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating thioether-linked active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Development: Used in the research and production of novel herbicides, fungicides, and insecticides containing sulfur-based functional groups.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized sulfur-containing ligands used in transition metal catalysis.
• Functional Material Research: Employed in the development of organic electronic materials, liquid crystals, and polymers with tailored properties.
• Cross-Coupling Reactions: A versatile reagent in Kumada and other transition-metal-catalyzed cross-coupling reactions to form biaryl and other complex structures.
• Nucleophilic Addition Reactions: Used for the addition to carbonyl compounds (aldehydes, ketones, esters) to form new alcohols and derivatives.

Basic Information

Product Name	4-Thioanisolemagnesium Bromide
CAS No.	18620-04-7
Molecular Formula	C7H7BrMgS
Molecular Weight	227.40 g/mol
Synonyms	p-(Methylthio)phenylmagnesium bromide; 4-(Methylthio)phenylmagnesium bromide; 4-Methylthiobenzene magnesium bromide; (4-Methylsulfanylphenyl)magnesium bromide; 1-Bromo-4-(methylthio)benzene magnesium; Grignard reagent of 4-bromothioanisole; p-Thioanisylmagnesium bromide
EINECS	Contact for details

Quality Control

Our 4-Thioanisolemagnesium Bromide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay (by titration), concentration in solution, and impurity profile. Our quality management system is designed to meet the exacting standards required for research and scale-up activities in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. This material is highly volatile and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. Keep the container in a cool, well-ventilated place, away from heat, sparks, and open flames. Due to its moisture-sensitive and pyrophoric nature, handle only under inert conditions using appropriate techniques.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light brown
Concentration	0.5 M in THF or as specified
Assay (Titration)	≥ 95%
Identification (IR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.