Description

4-Trifluoromethylphenylmagnesiumbromide is a highly reactive Grignard reagent, essential for introducing the versatile 4-(trifluoromethyl)phenyl group into molecular frameworks. This compound matters for its critical role in forming carbon-carbon bonds, enabling the synthesis of complex, high-value intermediates, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and advanced organic electronic compounds where the trifluoromethyl group enhances metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for APIs containing the trifluoromethylphenyl moiety, which is prevalent in drugs for oncology, CNS disorders, and inflammation.
• Agrochemical Active Ingredient Development: Used in the synthesis of herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Liquid Crystal and OLED Material Production: Serves as a precursor for creating advanced organic molecules used in display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions (e.g., Kumada coupling) to create biaryl structures common in material science and catalysis.
• Functionalized Polymer Chemistry: Used to incorporate aromatic trifluoromethyl groups into polymer backbones, modifying thermal and chemical resistance properties.
• Fine Chemical and Specialty Chemical Manufacturing: A versatile reagent for custom synthesis and contract manufacturing of complex, fluorinated organic molecules.

Basic Information

Product Name	4-Trifluoromethylphenylmagnesiumbromide
CAS No.	114855-97-9
Molecular Formula	C7H4BrF3Mg
Molecular Weight	249.31 g/mol
Synonyms	(4-(Trifluoromethyl)phenyl)magnesium bromide; 4-(Trifluoromethyl)phenylmagnesium bromide; p-Trifluoromethylphenylmagnesium bromide; α,α,α-Trifluoro-p-tolylmagnesium bromide; Magnesium, bromo[4-(trifluoromethyl)phenyl]-; 1-Bromo-4-(trifluoromethyl)benzene magnesium; Grignard reagent (4-CF3C6H4)MgBr
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylphenylmagnesiumbromide is manufactured under stringent quality systems. Each batch undergoes rigorous analytical testing, including titration for Grignard concentration and GC/HPLC analysis for purity and solvent content, to ensure consistency and reliability for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For extended stability, storage at 2-8°C is recommended. Keep away from heat, sparks, open flames, and strong oxidizing agents. Use appropriate ventilation and grounding procedures when handling.

Specification

Item	Specification
Appearance	Brown to dark brown solution
Concentration (in THF or Ether)	0.5 M - 1.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95%
Purity (GC/HPLC)	Contact for details
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.