Description

4-(1,3-Dioxan-2-Yl)Phenylmagnesium Bromide is a specialized organometallic reagent, specifically a Grignard reagent, widely used in advanced organic synthesis. Its core value lies in its ability to act as a powerful nucleophile for the formation of carbon-carbon bonds, enabling the construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for introducing the 4-(1,3-dioxan-2-yl)phenyl moiety into target molecules during the research and development of new drug candidates.
• Agrochemical Active Ingredient Production: Used in the synthesis of complex organic compounds for crop protection agents and herbicides.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Advanced Material Chemistry: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional materials requiring specific aromatic ether structures.
• Fine Chemical and Specialty Chemical Manufacturing: Integral to custom synthesis and scale-up processes for high-value, low-volume specialty chemicals.
• Academic and Industrial R&D: A valuable tool for methodological development and exploring new reaction pathways in organic chemistry laboratories.

Basic Information

Product Name	4-(1,3-Dioxan-2-Yl)Phenylmagnesium Bromide
CAS No.	125716-40-7
Molecular Formula	C12H15BrMgO2
Molecular Weight	295.46 g/mol
Synonyms	[4-(1,3-Dioxan-2-yl)phenyl]magnesium bromide; 2-[4-(Bromomagnesio)phenyl]-1,3-dioxane; 4-(1,3-Dioxan-2-yl)phenylmagnesium bromide solution; 4-(2,2-Dimethyl-1,3-dioxolan-4-yl)phenylmagnesium bromide (common misnomer for related compound); Grignard reagent of 4-(1,3-dioxan-2-yl)bromobenzene; p-(1,3-Dioxan-2-yl)phenylmagnesium bromide
EINECS	Contact for details

Quality Control

Every batch of our 4-(1,3-Dioxan-2-Yl)Phenylmagnesium Bromide is produced and handled under strict inert atmosphere conditions to ensure reactivity and purity. Quality is verified through rigorous analytical testing, including titration for Grignard concentration and GC/HPLC analysis for solvent purity and by-products. A comprehensive Certificate of Analysis (COA) detailing concentration, assay, and solvent specifications is provided with each shipment to guarantee consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C. Keep the container tightly sealed in a cool, dry, well-ventilated place. Separate from incompatible materials such as strong acids, water, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear solution, typically colorless to light brown
Concentration (in THF or Ether)	0.5 M - 1.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95%
Solvent	Specified (Tetrahydrofuran, Diethyl ether, or Toluene)
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.