Description

1-Pyridin-3-Yl-1,2,3,4-Tetrahydropyrrolo[1,2-A]Pyrazine is a high-purity, advanced pharmaceutical intermediate with a complex fused heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical development companies engaged in medicinal chemistry, process R&D, and the production of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis to explore new chemical entities (NCEs) with improved efficacy and selectivity.
• Process Development & Scale-up: Employed in optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing under cGMP guidelines.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CRAMOs) for custom synthesis projects and API production for clinical trials.
• Academic Research: Utilized in university and institutional labs for fundamental studies in heterocyclic chemistry and the development of new synthetic methodologies.

Basic Information

Product Name	1-Pyridin-3-Yl-1,2,3,4-Tetrahydropyrrolo[1,2-A]Pyrazine
CAS No.	865546-36-7
Molecular Formula	C15H15N3
Molecular Weight	237.30 g/mol
Synonyms	1-(Pyridin-3-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 3-(1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazin-1-yl)pyridine; Pyrrolo[1,2-a]pyrazine, 1-(3-pyridinyl)-1,2,3,4-tetrahydro-; 865546-36-7; 1-(3-Pyridyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
EINECS	Contact for details

Quality Control

Our 1-Pyridin-3-Yl-1,2,3,4-Tetrahydropyrrolo[1,2-A]Pyrazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate production. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.