Description

Resolvin E2 is a specialized pro-resolving lipid mediator (SPM) derived from the ω-3 fatty acid eicosapentaenoic acid (EPA). This compound plays a critical role in the active resolution of inflammation, offering a targeted mechanism distinct from conventional immunosuppression. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors focused on inflammation resolution, immunology, and metabolic disease research. The product is supplied as a high-purity reference standard and research chemical.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating the molecular mechanisms of inflammation resolution, tissue repair, and immune modulation.
• Drug Discovery & Development: Serves as a lead compound or pharmacodynamic marker for developing novel therapeutics targeting chronic inflammatory diseases, such as arthritis, asthma, and metabolic syndrome.
• Cell Biology & Signaling Studies: Applied in in vitro and ex vivo assays to study receptor-ligand interactions (e.g., ChemR23 receptor) and downstream signaling pathways.
• Metabolic Research: Investigated for its potential role in improving insulin sensitivity and resolving inflammation in adipose tissue and liver.
• Analytical Standard: Employed as a high-purity calibrant in LC-MS/MS, HPLC, and other analytical methods for the quantification of SPMs in biological samples.
• Nutraceutical & Cosmeceutical R&D: Explored for potential applications in advanced formulations aimed at promoting skin health and managing inflammatory skin conditions.

Basic Information

Product Name	Resolvin E2
CAS No.	865532-70-3
Molecular Formula	C22H32O5
Molecular Weight	376.49 g/mol
Synonyms	RvE2; 5S,6R,18R-Trihydroxy-7E,9E,11Z,14Z,16E-eicosapentaenoic acid; (5S,6R,18R)-5,6,18-Trihydroxyicosa-7E,9E,11Z,14Z,16E-pentaenoic acid; Resolvin E2 (RvE2); 18R-Resolvin E2; Specialized Pro-resolving Mediator E2
EINECS	Contact for details

Quality Control

Our Resolvin E2 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to cGMP principles for manufacturing control where applicable, and our analytical methods are validated to meet the stringent requirements of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Store away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.