Description

4-(2-Chloro-Acetylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. Its core value lies in its role as a versatile building block for constructing complex piperidine-based molecules, enabling the synthesis of targeted therapeutic agents. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting neurological and psychiatric disorders.
• Protease Inhibitor Synthesis: Used in the research and development of protease inhibitors for antiviral and anticancer therapies.
• Kinase Inhibitor Scaffolds: Serves as a core scaffold for the development of novel kinase inhibitors, a major class of targeted cancer drugs.
• Peptidomimetic Chemistry: Integral for creating peptidomimetics and modifying peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Research: Employed in the discovery of new agrochemicals, such as herbicides and fungicides, that utilize piperidine motifs.
• Chemical Biology Probes: Useful for synthesizing molecular probes to study enzyme function and biological pathways in academic and industrial research.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services and contract manufacturing organizations (CMOs) producing specialized fine chemicals.

Basic Information

Product Name	4-(2-Chloro-Acetylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	865432-01-5
Molecular Formula	C12H21ClN2O3
Molecular Weight	276.76 g/mol
Synonyms	1-Boc-4-(2-chloroacetamido)piperidine; tert-Butyl 4-[(2-chloroacetyl)amino]piperidine-1-carboxylate; 4-(2-Chloroacetamido)-1-Boc-piperidine; 1-Boc-4-(chloroacetylamino)piperidine; 4-(Chloroacetylamino)piperidine-1-carboxylic acid tert-butyl ester; N-(1-Boc-4-piperidinyl)-2-chloroacetamide; 865432-01-5; 4-(2-Chloroacetylamino)piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-(2-Chloro-Acetylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.