Description

4-(5-Chloro-Naphthalene-2-Sulfonyl)-Piperazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a distinct sulfonamide-piperazine structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel drug candidates, especially in areas requiring specific receptor modulation.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Protease Inhibitor Development: Potential scaffold for the development of enzyme inhibitors due to its sulfonamide moiety.
• Kinase Inhibitor Synthesis: Serves as a precursor in the creation of compounds designed to modulate kinase activity.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological processes and target validation.
• Custom Synthesis: Sourced by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthesis projects.

Basic Information

Product Name	4-(5-Chloro-Naphthalene-2-Sulfonyl)-Piperazine Hydrochloride
CAS No.	864759-58-0
Molecular Formula	C14H16Cl2N2O2S
Molecular Weight	347.26 g/mol
Synonyms	4-[(5-Chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride; 5-Chloro-2-naphthalenesulfonamide, N-(1-piperazinyl)-, hydrochloride; 4-(5-Chloro-2-naphthalenesulfonyl)piperazine hydrochloride; Piperazine, 4-[(5-chloro-2-naphthalenyl)sulfonyl]-, hydrochloride (1:1); 864759-58-0; UNII-8J7C0QY65Q; 8J7C0QY65Q
EINECS	Contact for details

Quality Control

Our 4-(5-Chloro-Naphthalene-2-Sulfonyl)-Piperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.