Description

4-(2-Trifluoromethoxy-Benzenesulfonyl)-Piperazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its sulfonyl piperazine core and trifluoromethoxy benzene moiety. This compound is essential for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system and other therapeutic areas. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of potential drug candidates, especially those requiring a sulfonylated piperazine scaffold.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study enzyme function and biological pathways.
• Process Chemistry Development: Employed in scaling up synthetic routes for Active Pharmaceutical Ingredient (API) production under cGMP conditions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	4-(2-Trifluoromethoxy-Benzenesulfonyl)-Piperazine Hydrochloride
CAS No.	864759-57-9
Molecular Formula	C12H14ClF3N2O3S
Molecular Weight	358.76 g/mol
Synonyms	4-[(2-Trifluoromethoxy)phenyl]sulfonylpiperazine hydrochloride; 1-[(2-Trifluoromethoxy)benzenesulfonyl]piperazine hydrochloride; Piperazine, 1-[(2-(trifluoromethoxy)phenyl)sulfonyl]-, hydrochloride (1:1); 4-(2-(Trifluoromethoxy)phenylsulfonyl)piperazine HCl; 864759-57-9 (CAS); 4-(2-Trifluoromethoxybenzenesulfonyl)piperazine HCl
EINECS	Contact for details

Quality Control

Our 4-(2-Trifluoromethoxy-Benzenesulfonyl)-Piperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.