Description

(S)-(2-[1,4]Diazepan-1-Yl-1-Methyl-2-Oxo-Ethyl)-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a chiral center and a protected amine group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of chiral drugs targeting the central nervous system. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of chiral APIs, especially for neurological and psychiatric drug candidates.
• Chiral Synthesis: Used in asymmetric synthesis to introduce the (S)-configuration into target molecules, ensuring high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Peptidomimetic Development: Utilized in the design and synthesis of peptidomimetics and protease inhibitors due to its diazepane and carbamate structure.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom intermediates for client projects.

Basic Information

Item	Details
Product Name	(S)-(2-[1,4]Diazepan-1-Yl-1-Methyl-2-Oxo-Ethyl)-Carbamic Acid tert-Butyl Ester
CAS No.	864754-27-8
Molecular Formula	C14H25N3O3
Molecular Weight	283.37 g/mol
Synonyms	(S)-tert-Butyl (2-(1,4-diazepan-1-yl)-1-methyl-2-oxoethyl)carbamate; (S)-Boc-Dap-OH(Diazepane); (S)-2-((tert-Butoxycarbonyl)amino)-2-(1,4-diazepan-1-yl)propanoic acid; (S)-N-Boc-2-(1,4-diazepan-1-yl)alanine; (S)-1-(N-Boc-α-amino)propionyl-1,4-diazepane; 864754-27-8; (S)-Boc-Aze(Diazepane)-OH
EINECS	Contact for details

Quality Control

Every batch of our (S)-(2-[1,4]Diazepan-1-Yl-1-Methyl-2-Oxo-Ethyl)-Carbamic Acid tert-Butyl Ester is produced under strict quality management systems. We guarantee high chemical and chiral purity, with comprehensive testing performed via HPLC, NMR, and optical rotation analysis. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to ensure compliance with your research and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.