Description

1-Benzyl-3-(2,2-Difluoro-Ethyl)-4-Oxo-Piperidine-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a versatile building block for creating novel therapeutic agents. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) focused on developing new drugs, particularly in areas requiring sophisticated piperidine-based scaffolds. The product, identified by CAS number 864685-19-8, is supplied with full traceability and quality documentation.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting central nervous system (CNS) disorders, pain management, and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with improved efficacy and safety profiles.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial drug substances.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug discovery methodologies.
• Custom Synthesis: A foundational compound for the custom synthesis of more complex, proprietary molecules for specific client projects.

Basic Information

Product Name	1-Benzyl-3-(2,2-Difluoro-Ethyl)-4-Oxo-Piperidine-3-Carboxylic Acid Ethyl Ester
CAS No.	864685-19-8
Molecular Formula	C18H23F2NO3
Molecular Weight	339.38 g/mol
Synonyms	Ethyl 1-Benzyl-3-(2,2-difluoroethyl)-4-oxopiperidine-3-carboxylate; 3-Piperidinecarboxylic acid, 1-benzyl-3-(2,2-difluoroethyl)-4-oxo-, ethyl ester; 1-Benzyl-3-(2,2-difluoroethyl)-4-oxo-3-piperidinecarboxylic acid ethyl ester; 864685-19-8; Ethyl 1-benzyl-3-(2,2-difluoroethyl)-4-oxopiperidine-3-carboxylate; 1-Benzyl-3-(2,2-difluoroethyl)-4-oxopiperidine-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 1-Benzyl-3-(2,2-Difluoro-Ethyl)-4-Oxo-Piperidine-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as assay, impurity profile, and residual solvents. Our quality commitment aligns with ICH guidelines and supports regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent exposure to atmospheric moisture. Store away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.