Description

4-Fluoro-1,4'-Bipiperidine 2Hcl is a high-purity, bifunctional piperidine derivative, primarily utilized as a sophisticated building block in advanced organic synthesis. Its value lies in its unique fluorinated bipiperidine scaffold, which is critical for modulating the physicochemical and pharmacological properties of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atom and piperidine rings enhance bioactivity and stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing molecular probes and enzyme inhibitors to study biological pathways.
• Ligand & Catalyst Development: Employed in the synthesis of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & Contract Research: A valuable reagent for universities and CROs conducting cutting-edge synthetic chemistry and medicinal chemistry programs.

Basic Information

Product Name	4-Fluoro-1,4'-Bipiperidine 2Hcl
CAS No.	864291-95-2
Molecular Formula	C10H20F N2 • 2HCl
Molecular Weight	279.20 g/mol (for free base: 187.28 g/mol)
Synonyms	1,4'-Bipiperidine, 4-fluoro-, dihydrochloride; 4-Fluoro-1,4'-bipiperidine dihydrochloride; 4-Fluorobipiperidine dihydrochloride; 1-(4-Fluoropiperidin-1-yl)piperidine dihydrochloride; 4-Fluoro-1,4'-dipiperidine 2HCl; 864291-95-2; FC-1012 (Potential Research Code)
EINECS	Contact for details

Quality Control

Our 4-Fluoro-1,4'-Bipiperidine 2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from advanced techniques like HPLC, NMR, and MS. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.