Description

4-(4-Methylpiperazin-1-Yl)-2-(Trifluoromethyl)Aniline is a high-value, multi-functional aromatic amine building block featuring a piperazine and a trifluoromethyl group. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs, kinase inhibitors, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers, dyes, and advanced organic electronic materials due to its electron-donating amine and electron-withdrawing CF3 group.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags, molecular probes, and other tools for biochemical research and diagnostics.

Basic Information

Product Name	4-(4-Methylpiperazin-1-Yl)-2-(Trifluoromethyl)Aniline
CAS No.	863675-89-2
Molecular Formula	C12H16F3N3
Molecular Weight	259.27 g/mol
Synonyms	2-(Trifluoromethyl)-4-(4-methyl-1-piperazinyl)aniline; 4-(4-Methylpiperazin-1-yl)-2-(trifluoromethyl)benzenamine; 1-Methyl-4-[2-(trifluoromethyl)-4-aminophenyl]piperazine; 2-(Trifluoromethyl)-4-(4-methylpiperazin-1-yl)aniline; 4-Amino-3-(trifluoromethyl)-N-methylpiperazine; 863675-89-2; 4-(4-Methyl-1-piperazinyl)-2-(trifluoromethyl)aniline
EINECS	Contact for details

Quality Control

Our 4-(4-Methylpiperazin-1-Yl)-2-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.