Description

tert-Butyl 3-(1H-Tetrazol-5-Yl)Morpholine-4-Carboxylate is a high-value, heterocyclic building block featuring both a tetrazole ring and a morpholine scaffold. This compound is critical for medicinal chemistry research and pharmaceutical development, serving as a versatile intermediate for constructing novel active molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of potential drug candidates and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Medicinal Chemistry Scaffold: Used to introduce the tetrazole moiety, a common bioisostere for carboxylic acids, into lead compounds to modulate pharmacokinetic properties like solubility, metabolic stability, and bioavailability.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, or insecticides, leveraging its heterocyclic structure for biological activity.
• Chemical Biology Probe Development: Serves as a building block for creating molecular probes to study enzyme function or protein-protein interactions within biological systems.
• Peptidomimetics: The morpholine-tetrazole structure can be incorporated into peptide analogs to enhance stability against enzymatic degradation.
• Ligand Synthesis for Catalysis: Potential use in constructing specialized ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	tert-Butyl 3-(1H-Tetrazol-5-Yl)Morpholine-4-Carboxylate
CAS No.	863646-43-9
Molecular Formula	C10H17N5O3
Molecular Weight	255.27 g/mol
Synonyms	4-Boc-3-(1H-tetrazol-5-yl)morpholine; tert-Butyl 3-(1H-tetrazol-5-yl)morpholine-4-carboxylate; 3-(1H-Tetrazol-5-yl)morpholine-4-carboxylic acid tert-butyl ester; Morpholine-4-carboxylic acid, 3-(1H-tetrazol-5-yl)-, 1,1-dimethylethyl ester; 4-(tert-Butoxycarbonyl)-3-(1H-tetrazol-5-yl)morpholine; Boc-3-tetrazolyl-morpholine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(1H-Tetrazol-5-Yl)Morpholine-4-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) standards for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.