Description

Balamapimod CAS NO 863029-99-6 is a potent and selective small molecule inhibitor targeting p38α MAP kinase, a key signaling protein involved in inflammatory pathways. This compound is crucial for research and development in the pharmaceutical industry, offering a valuable tool for studying inflammatory diseases and related therapeutic interventions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in drug discovery programs for conditions such as rheumatoid arthritis, Crohn's disease, and other inflammatory disorders.

Application

• Biochemical Research: Used as a selective p38α MAPK inhibitor to study intracellular signaling cascades and inflammatory response mechanisms in cell-based assays.
• Drug Discovery & Development: Serves as a key reference standard and pharmacologically active compound in high-throughput screening and lead optimization for novel anti-inflammatory therapeutics.
• Preclinical Studies: Employed in animal models to investigate the efficacy, pharmacokinetics, and toxicology of p38α inhibition for treating autoimmune and chronic inflammatory diseases.
• Mechanism of Action (MoA) Studies: Essential for elucidating the role of p38 MAPK in disease pathology and validating it as a therapeutic target.
• Academic Research: Utilized in university and institutional labs for fundamental research in immunology, cell biology, and molecular pharmacology.
• Biomarker Research: Applied in studies to identify and validate downstream biomarkers affected by p38α pathway modulation.

Basic Information

Product Name	Balamapimod
CAS No.	863029-99-6
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	BIRB 796; BIRB-796; BIRB796; 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea; N-[4-[2-(4-Morpholinyl)ethoxy]-1-naphthalenyl]-N'-[5-(1,1-dimethylethyl)-2-(4-methylphenyl)-3-pyrazolyl]urea; Doramapimod; p38α MAPK Inhibitor BIRB 796
EINECS	Contact for details

Quality Control

Our Balamapimod is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere or in a desiccator to maintain stability and prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.