Description

4-(2-Amino-4-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative featuring a trifluoromethylphenyl amine moiety. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry research, enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used to introduce the piperazine and trifluoromethylphenyl amine pharmacophores into novel chemical entities for structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Intermediate in the development of advanced crop protection agents and pesticides.
• Chemical Biology: Serves as a precursor for designing molecular probes and enzyme inhibitors.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	4-(2-Amino-4-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	862874-74-6
Molecular Formula	C16H22F3N3O2
Molecular Weight	345.36 g/mol
Synonyms	tert-Butyl 4-(2-amino-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate; 1-Boc-4-(2-amino-4-trifluoromethylphenyl)piperazine; 4-(2-Amino-4-trifluoromethylphenyl)piperazine-1-carboxylic acid tert-butyl ester; 862874-74-6; N-Boc-4-(2-amino-4-(trifluoromethyl)phenyl)piperazine; 1-(tert-Butoxycarbonyl)-4-[2-amino-4-(trifluoromethyl)phenyl]piperazine
EINECS	Contact for details

Quality Control

Our production of 4-(2-Amino-4-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.