Description

(3R)-3-Amino-1-[3-(Trifluoromethyl)-6,8-Dihydro-5H-[1,2,4]Triazolo[4,3-A]Pyrazin-7-Yl]-4-(2,4,5-Trifluorophenyl)Butan-1-One:Hydrochloric Acid Acid:Hydrate is a high-purity, non-racemic chiral intermediate of significant importance in modern pharmaceutical synthesis. Its complex heterocyclic structure, featuring multiple fluorine substituents, makes it a critical building block for developing potent and selective active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology industries, particularly those focused on central nervous system (CNS) and metabolic disease targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially those targeting G-protein-coupled receptors (GPCRs).
• Preclinical & Clinical Research: Serves as a critical reference standard and starting material for medicinal chemistry programs exploring triazolopyrazine-based therapeutics.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for new chemical entities (NCEs).
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the final stages or penultimate steps for constructing complex API molecules with defined stereochemistry.
• Biochemical Research: Potential use as a tool compound or ligand in biochemical assays and target validation studies due to its specific structural motifs.

Basic Information

Item	Details
Product Name	(3R)-3-Amino-1-[3-(Trifluoromethyl)-6,8-Dihydro-5H-[1,2,4]Triazolo[4,3-A]Pyrazin-7-Yl]-4-(2,4,5-Trifluorophenyl)Butan-1-One:Hydrochloric Acid Acid:Hydrate
CAS No.	862156-92-1
Molecular Formula	C₁₇H₁₆F₆N₅O₂ • HCl • xH₂O
Molecular Weight	Contact for details
Synonyms	(3R)-3-Amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride hydrate; 862156-92-1; UNII-7K3I4J5Z2B; 7K3I4J5Z2B; (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride hydrate; Butan-1-one, 3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)-, hydrochloride, hydrate, (3R)-; (3R)-3-Amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride hydrate
EINECS	Contact for details

Quality Control

This high-value pharmaceutical intermediate is manufactured under strict quality management systems. Every batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, strength, and compositional integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, enantiomeric excess, and impurity profiles. Our quality commitment aligns with ICH guidelines for impurities and supports development activities from preclinical through to commercial registration.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	Contact for details
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.