Description

4-Piperidineacetic Acid, 1-[(1,1-Dimethylethoxy)Carbonyl]-A,A-Dimethyl-, Methyl Ester is a high-purity, protected piperidine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within the central nervous system (CNS) and metabolic disorder therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Peptidomimetic Synthesis: Serves as a constrained, non-natural amino acid analog for creating peptide-like molecules with enhanced stability and bioavailability.
• Ligand and Probe Development: Utilized in constructing specialized chemical probes for biological target identification and validation in drug discovery.
• Process Chemistry Scale-up: Employed in the development and optimization of scalable, cost-effective synthetic routes for pilot and commercial-scale API manufacturing.
• Agrochemical Research: Potential intermediate in the synthesis of novel crop protection agents and pesticides requiring specific chiral or sterically hindered motifs.

Basic Information

Product Name	4-Piperidineacetic Acid, 1-[(1,1-Dimethylethoxy)Carbonyl]-A,A-Dimethyl-, Methyl Ester
CAS No.	861451-20-9
Molecular Formula	C15H27NO4
Molecular Weight	285.38 g/mol
Synonyms	1-Boc-4,4-dimethylpiperidine-4-acetic acid methyl ester; Methyl 1-(tert-butoxycarbonyl)-4,4-dimethyl-4-piperidineacetate; tert-Butyl 4-(2-methoxy-2-oxoethyl)-4,4-dimethylpiperidine-1-carboxylate; 4,4-Dimethyl-1-Boc-piperidine-4-acetic acid methyl ester; 1-N-Boc-4,4-dimethyl-4-piperidineacetic acid methyl ester; Boc-4,4-dimethyl-4-piperidineacetic acid methyl ester; (1-Boc-4,4-dimethylpiperidin-4-yl)acetic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-Piperidineacetic Acid, 1-[(1,1-Dimethylethoxy)Carbonyl]-A,A-Dimethyl-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.