Description

Serlopitant is a potent and selective small-molecule antagonist of the neurokinin-1 (NK1) receptor, a key target in the neurogenic pathway associated with pruritus (itching). This high-purity active pharmaceutical ingredient (API) is critical for the research and development of novel therapeutics targeting chronic pruritic conditions. It is primarily utilized by pharmaceutical companies and advanced research institutions engaged in dermatology, neurology, and inflammatory disease R&D programs.

Application

• Pharmaceutical Intermediate: Serves as the core active ingredient in the formulation of investigational new drugs targeting chronic pruritus.
• Clinical Research: Used in preclinical and clinical studies to evaluate the efficacy and safety of NK1 receptor antagonists for itch relief.
• Dermatological R&D: A key compound for developing treatments for conditions like atopic dermatitis, psoriasis, and uremic pruritus.
• Neurological Research: Employed in studies investigating the role of substance P and NK1 receptors in neurogenic inflammation and sensory signaling.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Mechanistic Studies: A vital tool for pharmacological research to understand and modulate the itch-scratch cycle.

Basic Information

Product Name	Serlopitant
CAS No.	860642-69-9
Molecular Formula	C₂₄H₂₈N₄O₂
Molecular Weight	404.51 g/mol
Synonyms	VPD-737; (R)-N-((3,5-Bis(trifluoromethyl)phenyl)methyl)-2-(4-fluorophenyl)-N,4-dimethyl-5-((methylsulfonyl)methyl)thiazole-3-carboxamide; (R)-N-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-2-(4-fluorophenyl)-N,4-dimethyl-5-[(methylsulfonyl)methyl]-3-thiazolecarboxamide; Serlopitant Maleate (salt form); NK1 Receptor Antagonist VPD-737
EINECS	Contact for details

Quality Control

Our Serlopitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.