Description

4-Arm PEG-VS is a multi-functional, tetravalent polyethylene glycol derivative featuring vinyl sulfone (VS) end groups, enabling efficient and stable conjugation with thiol-containing molecules. This compound is essential for creating highly defined, multi-arm crosslinked networks in advanced biomaterial and bioconjugation applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biomedical engineering, and diagnostics sectors for developing hydrogels, drug delivery systems, and protein-polymer conjugates.

Application

• Hydrogel Formation: Serves as a key crosslinker for creating injectable or implantable hydrogels for tissue engineering and 3D cell culture.
• Protein/Peptide PEGylation: Used for site-specific conjugation to cysteine residues, improving pharmacokinetics and stability of therapeutic biologics.
• Drug Delivery Systems: Facilitates the development of controlled-release matrices and nanoparticle coatings.
• Diagnostic Assays: Enables the stable immobilization of antibodies or probes onto sensor surfaces and microarrays.
• Biomaterial Functionalization: Modifies surfaces of medical devices or scaffolds to enhance biocompatibility and bioactivity.
• Linker for ADC Payloads: Acts as a versatile, branched linker in the synthesis of Antibody-Drug Conjugates (ADCs).

Basic Information

Product Name	4-Arm PEG-VS
CAS No.	860027-46-9
Molecular Formula	C(4n+8)H(8n+16)O(4n+4)S4 (n = PEG repeat units)
Molecular Weight	Variable (typically 2k, 5k, 10k, 20k Da). Contact for details.
Synonyms	4-Arm Polyethylene Glycol Vinylsulfone; Tetra-Arm PEG-Vinylsulfone; 4-Arm PEG-Vinyl Sulfone; Tetrabranched PEG-VS; PEG Tetra-Vinylsulfone; 4-Arm PEG-Vinylsulfonate Ester; Multi-Arm PEG-VS; Star-PEG-VS
EINECS	Contact for details

Quality Control

Our 4-Arm PEG-VS is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent functionality, and batch-to-batch reproducibility. Certificates of Analysis (COA) detailing specifications such as molecular weight distribution, degree of substitution, and purity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Complies
Assay (Functional Groups)	≥ 95%
Molecular Weight (Average)	As per ordered grade (e.g., 5,000 Da ± 10%)
Polydispersity Index (PDI)	≤ 1.05 (by GPC)
Degree of Substitution (VS)	≥ 3.8 / 4 arms
Water Content (KF)	≤ 1.0 %
Solubility	Clear, colorless solution in water and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.