Description

trans-4-(Boc-Amino)-3-Hydroxypiperidine CAS NO 859854-66-3 is a high-purity, protected piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold with orthogonal protecting groups, enabling the efficient construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of piperidine-based drug candidates, including kinase inhibitors, receptor antagonists, and central nervous system (CNS) active compounds.
• Peptidomimetics & Constrained Peptide Design: Used to introduce rigid, functionalized piperidine cores into peptide backbones to enhance metabolic stability and binding affinity.
• Library Synthesis for Drug Discovery: A versatile scaffold for generating diverse compound libraries in medicinal chemistry and high-throughput screening (HTS) campaigns.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and insecticides that utilize the piperidine motif.
• Chemical Biology Probes: Building block for creating molecular probes to study enzyme function and biological pathways.
• Asymmetric Catalysis Ligand Precursor: Potential precursor for chiral ligands and organocatalysts used in stereoselective transformations.

Basic Information

Product Name	trans-4-(Boc-Amino)-3-Hydroxypiperidine
CAS No.	859854-66-3
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	trans-4-[(tert-Butoxycarbonyl)amino]-3-hydroxypiperidine; (3R,4S)-4-[(tert-Butoxycarbonyl)amino]-3-hydroxypiperidine; (3S,4R)-4-[(tert-Butoxycarbonyl)amino]-3-hydroxypiperidine; trans-4-(N-Boc-amino)-3-hydroxypiperidine; 1-Boc-3-hydroxy-4-aminopiperidine (trans); 4-Amino-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester (trans); Boc-4-amino-3-hydroxypiperidine (trans); trans-4-(tert-Butoxycarbonylamino)-3-piperidinol
EINECS	Contact for details

Quality Control

Our trans-4-(Boc-Amino)-3-Hydroxypiperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.