Description

4-(4-Boc-Piperazin-1-Yl-Methyl)-2-Trifluoromethylaniline is a high-purity, advanced pharmaceutical intermediate featuring a Boc-protected piperazine moiety and a trifluoromethyl-substituted aniline core. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel drug candidates, especially in oncology and central nervous system (CNS) disease areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• Protease Inhibitor Development: Serves as a precursor in the creation of protease inhibitors, leveraging the piperazine scaffold.
• Kinase Inhibitor Synthesis: Employed in the construction of kinase inhibitor libraries for targeted cancer therapies.
• CNS Drug Discovery: Utilized in the development of compounds targeting neurological disorders due to the favorable properties of the trifluoromethyl group.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services.

Basic Information

Product Name	4-(4-Boc-Piperazin-1-Yl-Methyl)-2-Trifluoromethylaniline
CAS No.	859027-30-8
Molecular Formula	C18H26F3N3O2
Molecular Weight	373.42 g/mol
Synonyms	1-Boc-4-[(2-Amino-5-(trifluoromethyl)benzyl)]piperazine; tert-Butyl 4-[(2-amino-5-(trifluoromethyl)benzyl)]piperazine-1-carboxylate; 2-Trifluoromethyl-4-(4-Boc-piperazin-1-ylmethyl)aniline; 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)methyl]-2-(trifluoromethyl)aniline; 859027-30-8; N-Boc-4-((2-amino-5-(trifluoromethyl)phenyl)methyl)piperazine
EINECS	Contact for details

Quality Control

Every batch of 4-(4-Boc-Piperazin-1-Yl-Methyl)-2-Trifluoromethylaniline is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with ICH guidelines for impurities and stability. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.