Description

1-Boc-4-(3-Oxo-3-Phenylpropenyl)Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold protected by a tert-butoxycarbonyl (Boc) group and a chalcone-like side chain. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex molecules for drug discovery programs, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Building Block: Used to introduce the 4-(3-oxo-3-phenylpropenyl)piperidine moiety into lead compounds for structure-activity relationship (SAR) studies.
• Protease Inhibitor Synthesis: Serves as a core structural element in the development of protease inhibitors, including potential antiviral agents.
• Kinase Inhibitor Development: Employed in the construction of kinase inhibitor libraries for high-throughput screening and lead optimization.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of APIs (Active Pharmaceutical Ingredients) under cGMP conditions.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	1-Boc-4-(3-Oxo-3-Phenylpropenyl)Piperidine
CAS No.	858644-32-3
Molecular Formula	C19H25NO3
Molecular Weight	315.41 g/mol
Synonyms	1-Boc-4-(3-oxo-3-phenyl-1-propenyl)piperidine; tert-Butyl 4-(3-oxo-3-phenylprop-1-en-1-yl)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(3-oxo-3-phenylpropenyl)piperidine; 4-(3-Oxo-3-phenyl-1-propenyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-Boc-4-cinnamoylpiperidine; 858644-32-3; BOC-4-(3-Oxo-3-Phenylpropenyl)Piperidine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(3-Oxo-3-Phenylpropenyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed HPLC/GC data are provided for every shipment. We support development with custom purity grades and specifications aligned with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0% (Area Percent)
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.