Description

Ethyl 4-(1-{4-[(Difluoromethyl)Sulfanyl]Phenyl}-2,5-Dioxo-3-Pyrrolidinyl)-1-Piperazinecarboxylate is a high-value, complex heterocyclic compound featuring a maleimide core linked to a piperazinecarboxylate ester via a phenylsulfanyl bridge. This compound is a critical pharmaceutical intermediate and research chemical used in the development of novel therapeutic agents. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for constructing targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly for targeted therapies.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a versatile linker component due to its maleimide group for conjugation and piperazine moiety for solubility and spacing.
• Bioconjugation Chemistry: The maleimide functionality allows for selective thiol coupling, useful in antibody-drug conjugate (ADC) research and protein labeling.
• Kinase Inhibitor Research: Used as a core scaffold or intermediate in the design and synthesis of novel kinase inhibitors.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthetic routes and scale-up projects.

Basic Information

Product Name	Ethyl 4-(1-{4-[(Difluoromethyl)Sulfanyl]Phenyl}-2,5-Dioxo-3-Pyrrolidinyl)-1-Piperazinecarboxylate
CAS No.	857494-09-8
Molecular Formula	C19H21F2N3O4S
Molecular Weight	425.45 g/mol
Synonyms	Ethyl 4-(1-(4-((difluoromethyl)thio)phenyl)-2,5-dioxo-3-pyrrolidinyl)-1-piperazinecarboxylate; 1-Piperazinecarboxylic acid, 4-[1-[4-[(difluoromethyl)thio]phenyl]-2,5-dioxo-3-pyrrolidinyl]-, ethyl ester; Ethyl 4-(1-(4-((difluoromethyl)sulfanyl)phenyl)-2,5-dioxo-3-pyrrolidinyl)piperazine-1-carboxylate; 857494-09-8; CAS 857494-09-8
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.