Description

4-[3-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-Propyl] -Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for complex synthesis pathways. This compound is critical for research and development in medicinal chemistry, offering a versatile building block for constructing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in the discovery and optimization of new chemical entities (NCEs) for therapeutic applications.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a crucial linker component in the design of bifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Synthesis: Employed in the construction of piperazine-containing scaffolds common in kinase inhibitor libraries.
• Peptidomimetic Chemistry: Facilitates the introduction of piperazine and phthalimide functionalities into peptide-like structures to enhance stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	4-[3-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-Propyl] -Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	857266-28-5
Molecular Formula	C20H27N3O4
Molecular Weight	373.45 g/mol
Synonyms	2-[3-[4-(tert-Butoxycarbonyl)piperazin-1-yl]propyl]isoindole-1,3-dione; tert-Butyl 4-[3-(1,3-dioxoisoindol-2-yl)propyl]piperazine-1-carboxylate; 1-Boc-4-(3-phthalimidopropyl)piperazine; N-Boc-4-(3-phthalimidopropyl)piperazine; 857266-28-5; 4-(3-PHTHALIMIDOPROPYL)-1-PIPERAZINECARBOXYLIC ACID TERT-BUTYL ESTER; 1-Piperazinecarboxylic acid, 4-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-[3-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-Propyl] -Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the original container tightly sealed under inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.