Description

4-(3-Chloro-4-Formyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine and benzaldehyde functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of receptor-targeted therapies. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery and production of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those targeting neurological and oncological pathways.
• API (Active Pharmaceutical Ingredient) Synthesis: Serves as a crucial precursor in multi-step synthetic routes for final active compounds.
• Medicinal Chemistry Research: Used in research and development (R&D) for structure-activity relationship (SAR) studies and lead optimization.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production.
• Bioconjugation & Probe Development: The formyl group enables its use in bioconjugation chemistry for creating diagnostic probes or antibody-drug conjugates (ADCs).

Basic Information

Product Name	4-(3-Chloro-4-Formyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	855524-34-4
Molecular Formula	C16H21ClN2O3
Molecular Weight	324.80 g/mol
Synonyms	1-Boc-4-(3-chloro-4-formylphenyl)piperazine; tert-Butyl 4-(3-chloro-4-formylphenyl)piperazine-1-carboxylate; 4-(3-Chloro-4-formylphenyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(3-chloro-4-formylphenyl)piperazine; N-Boc-3-chloro-4-piperazinylbenzaldehyde; 3-Chloro-4-(1-Boc-piperazin-4-yl)benzaldehyde; 855524-34-4; Boc-3-chloro-4-piperazinylbenzaldehyde
EINECS	Contact for details

Quality Control

Our 4-(3-Chloro-4-Formyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by HPLC, NMR, and mass spectrometry. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.