Description

4-(4-Cbz-Piperazin-1-Yl-Methyl)-2-Trifluoromethylaniline is a high-purity, advanced pharmaceutical intermediate featuring a piperazine scaffold with protective and reactive functional groups. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, especially those containing piperazine and trifluoromethylphenyl motifs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• CNS Drug Development: Serves as a precursor in the development of potential neuropharmacological compounds.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of proprietary compounds and APIs.
• Chemical Biology Probes: Can be utilized to create molecular probes for studying biological pathways and target engagement.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	4-(4-Cbz-Piperazin-1-Yl-Methyl)-2-Trifluoromethylaniline
CAS No.	853297-17-3
Molecular Formula	C21H24F3N3O2
Molecular Weight	407.43 g/mol
Synonyms	4-[(4-[(Benzyloxy)carbonyl]-1-piperazinyl)methyl]-2-(trifluoromethyl)aniline; 4-[(4-Cbz-piperazin-1-yl)methyl]-2-(trifluoromethyl)aniline; 2-Trifluoromethyl-4-(4-Cbz-piperazin-1-ylmethyl)aniline; 4-(4-Cbz-Piperazin-1-Yl-Methyl)-2-Trifluoromethyl-Benzenamine; 853297-17-3; 4-(4-Carbobenzyloxy-piperazin-1-ylmethyl)-2-trifluoromethylaniline; 4-(N-Cbz-piperazin-1-ylmethyl)-2-trifluoromethylaniline
EINECS	Contact for details

Quality Control

Our 4-(4-Cbz-Piperazin-1-Yl-Methyl)-2-Trifluoromethylaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.