Description

2,5-Diazabicyclo[2.2.1]Heptane-2-Carboxylic Acid, 6-Oxo-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a constrained bicyclic diamine scaffold. This compound is valued for its role as a critical building block in the synthesis of complex molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies for the development of novel therapeutics, including protease inhibitors and other bioactive agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for targeted therapies.
• Protease Inhibitor Synthesis: Serves as a core structural component in the creation of potent inhibitors for various proteolytic enzymes.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies due to its rigid, three-dimensional architecture.
• Peptidomimetic Development: Employed to construct conformationally restricted peptide analogs that enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce stereoselectivity.
• Chemical Biology Research: Acts as a molecular scaffold for designing probes and tools to study enzyme function and biological pathways.

Basic Information

Item	Details
Product Name	2,5-Diazabicyclo[2.2.1]Heptane-2-Carboxylic Acid, 6-Oxo-, 1,1-Dimethylethyl Ester
CAS No.	852875-99-1
Molecular Formula	C11H18N2O3
Molecular Weight	226.27 g/mol
Synonyms	tert-Butyl 6-oxo-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate; (1R,4S)-tert-Butyl 6-oxo-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate; 2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid, 6-oxo-, 1,1-dimethylethyl ester; 2-N-Boc-2,5-diazabicyclo[2.2.1]heptan-6-one; Boc-DABN; 2,5-Diazabicyclo[2.2.1]heptan-6-one, 2-(tert-butoxycarbonyl)-
EINECS	Contact for details

Quality Control

Our 2,5-Diazabicyclo[2.2.1]Heptane-2-Carboxylic Acid, 6-Oxo-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure stereochemical integrity, meeting the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.