Description

Dutogliptin CAS NO 852329-66-9 is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, a key class of compounds in the management of type 2 diabetes. Its primary value lies in its role as a high-purity pharmaceutical intermediate or active pharmaceutical ingredient (API) for the development of novel antidiabetic therapeutics. This product is essential for pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and companies engaged in the synthesis of advanced drug candidates targeting metabolic disorders.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the formulation of investigational or commercial antidiabetic medications.
• Critical pharmaceutical intermediate for the synthesis of DPP-4 inhibitor class drugs in advanced manufacturing processes.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Key material in preclinical and clinical research studies focused on diabetes and metabolic syndrome.
• Building block for medicinal chemistry research and the development of new chemical entities with improved pharmacokinetic profiles.

Basic Information

Product Name	Dutogliptin
CAS No.	852329-66-9
Molecular Formula	C₁₇H₂₅FN₄O₂
Molecular Weight	336.41 g/mol
Synonyms	Dutogliptin; (R)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile; PHX1149; TS-021; 1-((R)-3-Amino-1-piperidinyl)-4-((4-fluoro-2-cyanophenyl)methyl)-2-methyl-1,2-dihydro-3H-pyrimidine-3,5-dione
EINECS	Contact for details

Quality Control

Our Dutogliptin is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical use. Quality is assured through comprehensive analytical testing, including HPLC, NMR, and MS, to verify identity, purity, and impurity profiles. We provide full traceability and Certificates of Analysis (COA) are available for every batch, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.