Description

tert-Butyl 4-[3-[(Methylamino)Methyl]Benzyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and manufacturing who require reliable, high-quality intermediates for complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• API Synthesis: Integral in the multi-step manufacturing process of final active pharmaceutical ingredients, requiring stringent purity controls.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	tert-Butyl 4-[3-[(Methylamino)Methyl]Benzyl]Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	852180-48-4
Molecular Formula	C18H29N3O2
Molecular Weight	319.44 g/mol
Synonyms	1-Boc-4-[3-[(Methylamino)Methyl]Benzyl]Piperazine; tert-Butyl 4-(3-((Methylamino)Methyl)Benzyl)Piperazine-1-Carboxylate; 1-(tert-Butoxycarbonyl)-4-[3-[(Methylamino)Methyl]Benzyl]Piperazine; 852180-48-4; 4-[3-[(Methylamino)Methyl]Benzyl]-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester; N-Boc-4-(3-((Methylamino)Methyl)Benzyl)Piperazine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical methods including HPLC, GC, and NMR. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development under cGMP guidelines as required for pharmaceutical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.