Description

tert-Butyl 4-[4-(Aminomethyl)Phenyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is a high-purity, protected amine derivative featuring a piperazine core, serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Protease Inhibitor Research: Used in the development of inhibitors for various proteolytic enzymes due to its amine-protected, modifiable structure.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing peptide mimics with enhanced metabolic stability and bioavailability.
• Ligand Synthesis for Drug Discovery: Employed in creating novel ligands for G-protein-coupled receptors (GPCRs) and kinases.
• Chemical Biology Probes: Utilized as a starting material for synthesizing probes to study enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental component for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	tert-Butyl 4-[4-(Aminomethyl)Phenyl]Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	852180-47-3
Molecular Formula	C16H25N3O2
Molecular Weight	291.39 g/mol
Synonyms	1-Boc-4-(4-(aminomethyl)phenyl)piperazine; tert-Butyl 4-(4-(aminomethyl)phenyl)piperazine-1-carboxylate; 4-(4-Aminomethylphenyl)-1-piperazinecarboxylic acid tert-butyl ester; 1-N-Boc-4-(4-aminomethylphenyl)piperazine; 852180-47-3; 4-[4-(Aminomethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[4-(Aminomethyl)Phenyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.