Description

1-[Bis(4-Fluorophenyl)Methyl]-4-(4-Nitrophenyl)Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct piperazine core flanked by fluorinated and nitrated aromatic systems. This compound matters for its critical role in the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and psychiatric drug discovery. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise building block to synthesize potential drug candidates targeting specific receptor pathways with enhanced selectivity and metabolic stability.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel psychotropic and neuroactive drug candidates.
• Chemical Biology Research: Used as a molecular scaffold or probe in structure-activity relationship (SAR) studies to understand ligand-receptor interactions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Medicinal Chemistry: Integral for the synthesis of compounds targeting serotonin, dopamine, or adrenergic receptors due to its piperazine pharmacophore.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial APIs for clinical trials.
• Life Science Reagents: Utilized in biochemical assays and high-throughput screening (HTS) libraries.

Basic Information

Item	Details
Product Name	1-[Bis(4-Fluorophenyl)Methyl]-4-(4-Nitrophenyl)Piperazine
CAS No.	851472-82-7
Molecular Formula	C23H21F2N3O2
Molecular Weight	409.43 g/mol
Synonyms	1-[(4,4'-Difluorodiphenyl)methyl]-4-(4-nitrophenyl)piperazine; 4-(4-Nitrophenyl)-1-[bis(4-fluorophenyl)methyl]piperazine; 1-(Bis(4-fluorophenyl)methyl)-4-(4-nitrophenyl)piperazine; 1-[(Bis(4-fluorophenyl))methyl]-4-(4-nitrophenyl)piperazine; 851472-82-7; 1-[Bis(4-fluorophenyl)methyl]-4-(4-nitrophenyl)piperazine; 4-Nitrophenyl-1-[(4,4'-difluorobenzhydryl)]piperazine
EINECS	Contact for details

Quality Control

Our 1-[Bis(4-Fluorophenyl)Methyl]-4-(4-Nitrophenyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider conditions under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.