Description

1-[4-Fluoro-2-(Methylsulfonyl)Phenyl]Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct sulfonyl and fluorinated aromatic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by R&D laboratories, process development chemists, and manufacturers in the global pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological disorders.
• CNS Drug Development: Used in research and production of potential antipsychotic, antidepressant, and anxiolytic agents due to its piperazine moiety.
• Kinase Inhibitor Synthesis: Serves as a building block for creating targeted cancer therapies, leveraging the methylsulfonylphenyl group.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new chemical entities and structure-activity relationships (SAR).
• Process Chemistry & Scale-up: Used in optimizing synthetic routes from milligram to kilogram scale for clinical trial material production.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	1-[4-Fluoro-2-(Methylsulfonyl)Phenyl]Piperazine
CAS No.	849938-78-9
Molecular Formula	C11H15FN2O2S
Molecular Weight	258.31 g/mol
Synonyms	1-(4-Fluoro-2-methanesulfonylphenyl)piperazine; 4-Fluoro-2-(piperazin-1-yl)phenyl methyl sulfone; 1-(4-Fluoro-2-(methylsulfonyl)phenyl)piperazine; 849938-78-9; 4-Fluoro-2-(methylsulfonyl)-1-(piperazin-1-yl)benzene; 2-(Methylsulfonyl)-4-fluorophenylpiperazine
EINECS	Contact for details

Quality Control

Our 1-[4-Fluoro-2-(Methylsulfonyl)Phenyl]Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.