Description

3-Ethoxycarbonylmethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. Its primary importance lies in its role as a versatile intermediate for constructing complex pharmacologically active molecules, particularly in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require reliable, high-purity intermediates for API development and fine chemical production.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, including kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Medicinal Chemistry Research: Used in combinatorial chemistry and parallel synthesis for creating diverse compound libraries for high-throughput screening (HTS).
• Peptidomimetic Synthesis: Serves as a constrained scaffold or a protected amine component in the design and synthesis of peptide analogs and mimetics.
• Agrochemical Development: Intermediate in the production of advanced crop protection agents and pesticides requiring specific piperazine-based architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	3-Ethoxycarbonylmethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	849547-86-0
Molecular Formula	C14H26N2O4
Molecular Weight	286.37 g/mol
Synonyms	1-Boc-3-(ethoxycarbonylmethyl)piperazine; tert-Butyl 3-(ethoxycarbonylmethyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(ethoxycarbonylmethyl)piperazine; 3-(Ethoxycarbonylmethyl)-1-Boc-piperazine; 1-Boc-3-(carbethoxymethyl)piperazine; 3-Carbethoxymethyl-1-Boc-piperazine; Piperazine-1-carboxylic acid, 3-[(ethoxycarbonyl)methyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-Ethoxycarbonylmethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications for research, development, and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.