Description

Ligustrazinephosphate CAS NO 848645-86-3 is a high-purity phosphate salt derivative of ligustrazine, a key bioactive alkaloid. This compound is valued for its enhanced stability and bioavailability compared to the base alkaloid, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily sought by manufacturers in the pharmaceutical and fine chemical industries for the research and development of cardiovascular and cerebrovascular therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting blood circulation and microvascular health.
• Cardiovascular Drug Research: Used in R&D for developing drugs aimed at improving cerebral blood flow, treating angina, and managing ischemic conditions.
• Fine Chemical Synthesis: Serves as a crucial precursor in the multi-step synthesis of complex organic molecules for medicinal chemistry.
• Reference Standard: Employed as an analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.
• Biochemical Research: Utilized in preclinical studies to investigate mechanisms of vasodilation and platelet aggregation inhibition.

Basic Information

Product Name	Ligustrazinephosphate
CAS No.	848645-86-3
Molecular Formula	C8H12N2·H3PO4 / C8H15N2O4P
Molecular Weight	234.19 g/mol (for C8H15N2O4P)
Synonyms	2,3,5,6-Tetramethylpyrazine phosphate; Tetramethylpyrazine phosphate; Ligustrazine phosphate; Chuanxiongzine phosphate; TMPZ phosphate; Pyrazine, tetramethyl-, phosphate (1:1); 848645-86-3
EINECS	Contact for details

Quality Control

Our Ligustrazinephosphate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.