Description

Phentolamine Mesilate is a potent, competitive non-selective α-adrenergic receptor antagonist. This compound is critical for its vasodilatory effects, making it a key pharmaceutical intermediate and research chemical. It is primarily utilized in the synthesis of active pharmaceutical ingredients (APIs) and in biochemical research for studying autonomic nervous system regulation. Our high-purity grade ensures reliability for demanding pharmaceutical development and production processes.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of final drug formulations targeting hypertension and pheochromocytoma.
• Biochemical Research: Used in laboratory studies to investigate α-adrenergic receptor mechanisms, signal transduction, and vascular physiology.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical testing laboratories.
• Vasodilatory Studies: Employed in preclinical research models to induce controlled vasodilation and study peripheral blood flow.
• API Manufacturing: Integral component in the commercial-scale production of phentolamine mesylate active pharmaceutical ingredient under GMP conditions.

Basic Information

Product Name	Phentolamine Mesilate
CAS No.	65-28-1
Molecular Formula	C17H19N3O·CH4O3S
Molecular Weight	377.43 g/mol
Synonyms	Phentolamine Mesylate; Phentolamine Methanesulfonate; 3-[(4,5-Dihydro-1H-imidazol-2-yl)methylamino]phenol monomethanesulfonate; Regitine; Rogitine; Phentolaminum; C7335; Fentolamina; (Contact for additional synonyms)
EINECS	200-603-5

Quality Control

Our Phentolamine Mesilate is manufactured and tested to meet high-purity standards suitable for pharmaceutical research and development. Each batch undergoes rigorous analytical testing including identification, assay, and impurity profiling. While we offer various grades, our standard quality control includes compliance with in-house specifications designed to ensure batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.