Description

Fasudil Hydrochloride is a potent and selective inhibitor of Rho-associated protein kinase (ROCK), a key enzyme involved in cellular signaling pathways. This compound is of significant value in pharmaceutical research and development, particularly for investigating cardiovascular and neurological disorders. It is primarily required by research institutions, pharmaceutical companies, and biotechnology firms engaged in drug discovery and preclinical studies for conditions such as cerebral vasospasm, pulmonary arterial hypertension, and glaucoma.

Application

• Pharmaceutical R&D: A critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of therapeutics targeting Rho-kinase pathways.
• Cardiovascular Research: Used in studies exploring treatments for hypertension, angina, and pulmonary arterial hypertension due to its vasodilatory effects.
• Neurological Research: Investigated for its neuroprotective potential in models of stroke, cerebral vasospasm following subarachnoid hemorrhage, and spinal cord injury.
• Ophthalmic Research: Applied in research for glaucoma and other ocular conditions by studying its effect on intraocular pressure and ocular blood flow.
• Cell Biology & Signal Transduction: A essential tool compound for studying the role of ROCK in cytoskeletal dynamics, cell migration, proliferation, and apoptosis.
• Biochemical Assays: Serves as a key inhibitor in enzymatic assays to characterize ROCK activity and screen for novel modulators.

Basic Information

Product Name	Fasudil Hydrochloride
CAS No.	105628-07-7
Molecular Formula	C14H17N3O2S • HCl
Molecular Weight	327.83 g/mol
Synonyms	HA-1077 Dihydrochloride; AT-877; Fasudil HCl; 5-Isoquinolinesulfonamide, 1-(5-isoquinolinylsulfonyl)homopiperazine, monohydrochloride; (1-(5-Isoquinolinesulfonyl)homopiperazine Hydrochloride); ERIL; Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine Hydrochloride
EINECS	Contact for details

Quality Control

Our Fasudil Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high-grade standards suitable for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods (e.g., HPLC, NMR) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.