Description

1,2,4-Triazolo[4,3-A]Pyrazine, 7-[3-Amino-1-Oxo-4-(2,4,5-Trifluorophenyl)-2-Butenyl]-5,6,7,8-Tetrahydro- 3-(Trifluoromethyl)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and development programs.

Application

This specialized intermediate is designed for high-value synthetic applications, particularly in medicinal chemistry. Its primary and potential uses include:

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of target drug molecules, especially those with triazolopyrazine cores.
• API Synthesis: Used in research-scale and process development for constructing complex APIs targeting various therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Bioconjugation & Probe Development: The reactive amino and ketone functionalities allow for further derivatization to create labeled compounds or probes for biological studies.

Basic Information

Product Name	1,2,4-Triazolo[4,3-A]Pyrazine, 7-[3-Amino-1-Oxo-4-(2,4,5-Trifluorophenyl)-2-Butenyl]-5,6,7,8-Tetrahydro- 3-(Trifluoromethyl)-
CAS No.	847445-81-2
Molecular Formula	C₁₆H₁₃F₆N₅O
Molecular Weight	405.30 g/mol
Synonyms	7-[3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine; UNII-6S0S6BZ5QH; 6S0S6BZ5QH; 1,2,4-Triazolo[4,3-a]pyrazine, 7-[3-amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-; Apremilast Intermediate; CCG-222978; BDBM50111685; AKOS015915889.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment. We support development and cGMP-grade requirements, with specifications tailored to client needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.