Description

1-Boc-4-(4-Bromo-Benzylamino)-Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine scaffold with a brominated aromatic side chain. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery and scale-up of new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize lead compounds for potency and selectivity.
• Process Chemistry Development: Serves as a starting material or intermediate in the development of scalable, GMP-compliant synthetic routes for APIs.
• Chemical Biology Probes: Employed in the creation of tool compounds for target validation and pathway analysis in biological systems.
• Custom Synthesis: A versatile substrate for contract manufacturing organizations (CMOs) offering bespoke chemical synthesis services.

Basic Information

Product Name	1-Boc-4-(4-Bromo-Benzylamino)-Piperidine
CAS No.	846605-66-1
Molecular Formula	C17H25BrN2O2
Molecular Weight	369.30 g/mol
Synonyms	1-Boc-4-[(4-Bromophenyl)methylamino]piperidine; tert-Butyl 4-[(4-bromobenzyl)amino]piperidine-1-carboxylate; 4-[(4-Bromobenzyl)amino]-1-(tert-butoxycarbonyl)piperidine; 1-(tert-Butoxycarbonyl)-4-[(4-bromobenzyl)amino]piperidine; Piperidine, 4-[(4-bromophenyl)methyl]amino]-1-[(1,1-dimethylethoxy)carbonyl]-; 846605-66-1; 1-Boc-4-(4-bromobenzylamino)piperidine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(4-Bromo-Benzylamino)-Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal quality standards and regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.