Description

(1S,4S)-(+)-2-Isobutyl-2,5-Diaza-Bicyclo[2.2.1]Heptane Dihydrochloride is a high-purity, chiral bicyclic diamine derivative supplied as a stable dihydrochloride salt. This compound serves as a critical advanced pharmaceutical intermediate and a versatile chiral building block for the synthesis of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral scaffold in the synthesis of novel drug candidates targeting neurological disorders.
• Ligand Synthesis: Used in the preparation of chiral ligands for asymmetric catalysis and metal complexation.
• Medicinal Chemistry Research: Serves as a constrained diamine building block for structure-activity relationship (SAR) studies and library synthesis.
• Process Chemistry: Employed in the development and scale-up of optimized synthetic routes for API manufacturing.
• Chemical Biology: Utilized as a molecular probe or tag due to its rigid, three-dimensional structure and amine functionality.

Basic Information

Product Name	(1S,4S)-(+)-2-Isobutyl-2,5-Diaza-Bicyclo[2.2.1]Heptane Dihydrochloride
CAS No.	845866-62-8
Molecular Formula	C9H19N2·2HCl
Molecular Weight	239.18 g/mol
Synonyms	(1S,4S)-(+)-2-Isobutyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride; (1S,4S)-2-(2-Methylpropyl)-2,5-diazabicyclo[2.2.1]heptane dihydrochloride; (+)-2-Isobutyl-2,5-diaza-bicyclo[2.2.1]heptane dihydrochloride; (1S,4S)-2-Isobutyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride; 2,5-Diaza-2-isobutylbicyclo[2.2.1]heptane dihydrochloride; Bicyclo[2.2.1]heptane-2,5-diamine, 2-(2-methylpropyl)-, hydrochloride (1:2), (1S,4S)-
EINECS	Contact for details

Quality Control

Our (1S,4S)-(+)-2-Isobutyl-2,5-Diaza-Bicyclo[2.2.1]Heptane Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.