Description

4-(2-Trifluoromethylpyrimidin-5-Yl)-1-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, multi-functional chemical building block designed for advanced synthesis. This compound matters because it provides a protected piperazine core linked to a functionalized pyrimidine ring, enabling efficient and modular construction of complex molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including kinase inhibitors and other biologically relevant heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for targeted therapies.
• Kinase Inhibitor Scaffold: Used in the synthesis of potential inhibitors for various kinases due to the privileged pyrimidine-piperazine structure.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, or insecticides with enhanced properties.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and advanced intermediates on a commercial scale.
• Academic & Institutional Research: Utilized in university and research institute laboratories for exploratory synthetic chemistry and medicinal chemistry programs.

Basic Information

Product Name	4-(2-Trifluoromethylpyrimidin-5-Yl)-1-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	845618-09-9
Molecular Formula	C14H18F3N5O2
Molecular Weight	345.32 g/mol
Synonyms	1-Boc-4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazine; tert-Butyl 4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazine; Boc-4-(2-Trifluoromethylpyrimidin-5-yl)piperazine; 4-(5-(Trifluoromethyl)pyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(5-trifluoromethyl-2-pyrimidinyl)piperazine
EINECS	Contact for details

Quality Control

Our 4-(2-Trifluoromethylpyrimidin-5-Yl)-1-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.