Description

Tmc-207 CAS NO 843663-66-1 is a high-purity chemical compound, also known as Bedaquiline, which serves as a critical active pharmaceutical ingredient (API). This compound is of significant importance as a diarylquinoline antimycobacterial agent, specifically developed to address multidrug-resistant tuberculosis (MDR-TB). It is primarily needed by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the development of advanced anti-tuberculosis therapeutics.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of anti-tuberculosis drugs, specifically for treating multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis.
• Research & Development: A key reference standard and investigational compound in pharmacological and microbiological research focused on novel mechanisms of action against *Mycobacterium tuberculosis*.
• Preclinical Studies: Utilized in animal models to study the efficacy, pharmacokinetics, and safety profile of new TB treatment regimens.
• Analytical Standard: Serves as a certified reference material (CRM) for quality control and assay development in analytical laboratories.
• Drug Combination Studies: Investigated in combination with other anti-TB agents to develop more effective and shorter treatment courses.

Basic Information

Product Name	Tmc-207
CAS No.	843663-66-1
Molecular Formula	C32H31BrN2O2
Molecular Weight	555.51 g/mol
Synonyms	Bedaquiline; Bedaquiline Fumarate; TMC-207; R207910; (1R,2S)-1-(6-Bromo-2-methoxy-3-quinolyl)-4-dimethylamino-2-(1-naphthyl)-1-phenylbutan-2-ol; Sirturo; Bedaquiline (TMC207)
EINECS	Contact for details

Quality Control

Our Tmc-207 is manufactured under strict quality management systems, targeting high purity suitable for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to ensure identity, purity, and strength. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.