Description

Canagliflozin is a potent and selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, a key active pharmaceutical ingredient (API) in the treatment of type 2 diabetes. This compound matters for its ability to lower blood glucose levels by promoting renal glucose excretion, offering a distinct mechanism of action from other anti-diabetic agents. Pharmaceutical manufacturers and research institutions globally require high-purity Canagliflozin CAS NO 842133-18-0 for the formulation of finished dosage forms and for ongoing metabolic research.

Application

• Pharmaceutical API: Primary use as the active ingredient in oral anti-diabetic medications (e.g., tablets) for managing type 2 diabetes mellitus.
• Drug Formulation R&D: Used in the research and development of new fixed-dose combination therapies and novel drug delivery systems.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in pharmaceutical laboratories.
• Metabolic Disease Research: A critical tool in preclinical and clinical studies investigating SGLT2 inhibition, renal function, and cardiovascular outcomes.
• Generic Drug Manufacturing: Essential for companies producing bioequivalent generic versions of SGLT2 inhibitor-based medications.
• Biochemical Research: Used in studies to elucidate the precise mechanism of SGLT2 transport and its role in human physiology.

Basic Information

Product Name	Canagliflozin
CAS No.	842133-18-0
Molecular Formula	C24H25FO5S
Molecular Weight	444.52 g/mol
Synonyms	Canagliflozin; JNJ 28431754; TA-7284; (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol; Invokana (Brand Name); SGLT2 Inhibitor Canagliflozin; 1-(β-D-Glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)thiophen-2-ylmethyl]benzene
EINECS	Contact for details

Quality Control

Our Canagliflozin is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identification confirmation. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.10%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.