Description

[(5-Bromo-2-Thienyl)(4-tert-Butoxycarbonyl)-1,4-Diazepan-1-Yl]Acetic Acid is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters because it provides a critical, structurally defined building block essential for research and development in modern medicinal chemistry, ensuring precise molecular construction. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and academic institutions focused on developing novel therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel diazepane-based drug candidates targeting G-protein coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs for new therapeutic entities.
• API Development: Serves as a precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly those with heterocyclic architectures.
• Chemical Biology Probes: Utilized in the development of specialized molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by CROs and CDMOs for the contract manufacturing of bespoke compounds for client-specific drug discovery projects.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and novel chemical entities.

Basic Information

Product Name	[(5-Bromo-2-Thienyl)(4-tert-Butoxycarbonyl)-1,4-Diazepan-1-Yl]Acetic Acid
CAS No.	834884-89-8
Molecular Formula	C18H25BrN2O4S
Molecular Weight	445.37 g/mol
Synonyms	1,4-Diazepane-1-acetic acid, 4-[(1,1-dimethylethoxy)carbonyl]-α-(5-bromo-2-thienyl)-; 4-(tert-Butoxycarbonyl)-α-(5-bromo-2-thienyl)-1,4-diazepane-1-acetic acid; Boc-Protected 5-Bromothiophene Diazepane Acetic Acid; (5-Bromo-thiophen-2-yl)-(4-tert-butoxycarbonyl-[1,4]diazepan-1-yl)-acetic acid; UNII-Contact for details; 834884-89-8 (CAS); 5-Bromo-2-thienyl(4-Boc-1,4-diazepan-1-yl)acetic acid
EINECS	Contact for details

Quality Control

Our [(5-Bromo-2-Thienyl)(4-tert-Butoxycarbonyl)-1,4-Diazepan-1-Yl]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles are available for every lot. We support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.