Description

Rac 2-(Piperazin-1-yl)-propionic acid dihydrate is a versatile chiral piperazine derivative that serves as a critical building block in advanced organic synthesis. Its bifunctional structure, featuring both a carboxylic acid and a secondary amine, makes it an invaluable intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Ligand and Catalyst Preparation: Used in the synthesis of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics Research: Serves as a constrained scaffold or linker in the design of peptide analogs and bio-active molecules.
• Chemical Biology Probes: Foundation for creating molecular probes and tags used in biochemical assay development and diagnostic research.
• Polymer Modification: Functional monomer for introducing amine and acid groups into polymer backbones to modify material properties.

Basic Information

Product Name	Rac 2-(Piperazin-1-yl)-propionic acid dihydrate
CAS No.	825594-88-5
Molecular Formula	C7H14N2O2 · 2H2O
Molecular Weight	194.23 g/mol (Anhydrous basis: 158.20 g/mol)
Synonyms	DL-2-(Piperazin-1-yl)propionic acid dihydrate; (±)-2-(Piperazin-1-yl)propanoic acid dihydrate; 1-Piperazinepropanoic acid, dihydrate, racemic; 2-Piperazin-1-ylpropionic acid; rac-Piperazinepropionic acid; 825594-88-5; UNII-7F4F4V8A0H
EINECS	Contact for details

Quality Control

Our Rac 2-(Piperazin-1-yl)-propionic acid dihydrate is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Standard quality control includes identity confirmation, assay (purity), and control of specific impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support development and cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture from the air, which can affect product quality and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	15.0% - 18.5% (Theoretical for dihydrate: ~18.5%)
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Related Substances (HPLC)	Total impurities < 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.