Description

Methyl (2S,5R)-1-Cbz-5-Hydroxy-6-Methoxypipecolinate is a high-purity, non-natural amino acid derivative and a crucial chiral building block in advanced organic synthesis. This compound matters because it provides a stereochemically defined scaffold essential for constructing complex molecules with high biological specificity. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel active pharmaceutical ingredients (APIs), particularly in the areas of protease inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially protease inhibitors.
• Peptidomimetics Construction: Used to introduce constrained pipecolic acid motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a starting material or intermediate in stereoselective synthesis routes for complex natural products and bioactive molecules.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and enzyme inhibitors for mechanistic studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	Methyl (2S,5R)-1-Cbz-5-Hydroxy-6-Methoxypipecolinate
CAS No.	824943-45-5
Molecular Formula	C16H21NO6
Molecular Weight	323.34 g/mol
Synonyms	Methyl (2S,5R)-1-[(benzyloxy)carbonyl]-5-hydroxy-6-methoxypipecolate; (2S,5R)-Methyl 1-Cbz-5-hydroxy-6-methoxypipecolate; 1-Cbz-5-Hydroxy-6-methoxypipecolic Acid Methyl Ester; (2S,5R)-1-(Benzyloxycarbonyl)-5-hydroxy-6-methoxypipecolic Acid Methyl Ester; Methyl 1-Cbz-5-hydroxy-6-methoxypipecolinate; CAS 824943-45-5; Benzyl (2S,5R)-5-hydroxy-6-methoxy-2-(methoxycarbonyl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl (2S,5R)-1-Cbz-5-Hydroxy-6-Methoxypipecolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard spectroscopic methods for identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.