Description

2-(Piperazin-1-Yl)Propionic Acid Dihydrate is a high-purity, functionalized piperazine derivative that serves as a critical building block in advanced organic synthesis. Its bifunctional structure, featuring both a carboxylic acid and a secondary amine, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, especially those targeting the central nervous system (CNS) and as a linker for prodrug development.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require specific piperazine-based pharmacophores.
• Ligand and Chelator Precursor: Serves as a starting material for creating specialized ligands used in catalysis and metal chelation applications.
• Polymer Modification: Employed to introduce amine functionality into polymers, enhancing properties like adhesion, cross-linking potential, and biocompatibility.
• Bioconjugation Chemistry: Useful for creating linkers in antibody-drug conjugates (ADCs) and other bioconjugation strategies due to its reactive handles.
• Research & Development: A valuable tool for medicinal chemists in structure-activity relationship (SAR) studies and library synthesis for high-throughput screening.

Basic Information

Product Name	2-(Piperazin-1-Yl)Propionic Acid Dihydrate
CAS No.	824414-03-1
Molecular Formula	C7H14N2O2 • 2H2O
Molecular Weight	194.21 g/mol (Anhydrous Basis: 158.20 g/mol)
Synonyms	1-(2-Carboxyethyl)piperazine Dihydrate; 2-(1-Piperazinyl)propanoic Acid Dihydrate; β-(Piperazin-1-yl)propionic Acid Dihydrate; NSC 339586 Dihydrate; 2-Piperazin-1-ylpropionic Acid Dihydrate; 1-Piperazinepropionic Acid Dihydrate; (Piperazin-1-yl)acetic Acid Ethyl Homolog Dihydrate
EINECS	Contact for details

Quality Control

Our 2-(Piperazin-1-Yl)Propionic Acid Dihydrate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, Karl Fischer titration for water content, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	15.0% - 20.0% (Theoretical: 18.56%)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.